Atherosclerosis and Dyslipidaemias
نویسندگان
چکیده
Patients with diabetes mellitus are at increased risk of restenosis after coronary artery stenting. Chronic hyperglycemia is associated with advanced glycation end products excessive production. There are data that in-stent restenosis in patients with diabetes mellitus may be related to plasma level of advanced glycation end products. One of the reasons for this is that protein glycation by alteration of protein structure adversely affects their function. Another cause may be due to the interaction between advanced glycation end products and membrane-bound receptor for advanced glycation end-products. Experimental data indicate that blockade of receptor for advanced glycation end-products with soluble receptor for advanced glycation endproducts resulted in significantly decreased of neointimal expansion after arterial injury.
منابع مشابه
ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS).
Cardiovascular disease (CVD) due to atherosclerosis of the arterial vessel wall and to thrombosis is the foremost cause of premature mortality and of disability-adjusted life years (DALYs) in Europe, and is also increasingly common in developing countries.1 In the European Union, the economic cost of CVD represents annually E192 billion1 in direct and indirect healthcare costs. The main clinica...
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Professor Željko Reiner, FRCP (London), FESC, FACC gained his MD degree in 1976 from Zagreb University, Croatia. He also holds a PhD degree from Zagreb University. Currently, he is the head of the Department of Internal Medicine, University Hospital Centre Zagreb and the School of Medicine, Zagreb University. He has held many positions in the European Society of Cardiology (ESC) and European At...
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